MEDICAL NEWS TODAY, MAY 27, 2006
Of 869 patients who underwent radical prostatectomy at 3 VA Medical Centers, a history of Agent Orange exposure was identified in 10% of patients.
Patients with prior Agent Orange exposure were more likely to be younger, have T1 disease, lower serum PSA levels, but similar Gleason scores. Interestingly, although agent orange exposure was not associated with an increased incidence of more advanced Gleason scores or pathologic stage, patients in this group had an independently increased risk of biochemical progression (Hazard ratio = 1.95, 95% CI 1.22 to 3.11, p = 0.005).
This study with a small sample size warrants further analysis of the impact of Agent Orange exposure in prostate cancer progression.